HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 12606930, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| Reactant | 2-Acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride | HCID 12606904 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 12606930 | HCID 12606930 | — |
Reaction Steps
2-Acetyl-7-chlorosulphonyl-1,2,3,4-tetrahydroisoquinoline was reacted with 3-trifluoromethylaniline in dichloromethane according to the method generally described in EP No. 0038177-A. The resulting product was deacetylated by heating with aqueous hydrochloric acid in butanol to give 7-(3-trifluoromethylphenylsulphamoyl)-1,2,3,4-tetrahydroisoquinoline as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04812573 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-ed8a53660c84466bae1eabf18e1f8785 |
| Source note | uspto-grants-1989_03 |