反应详情

A stirred mixture of 5-amino-1,2,3,4-tetrahydroisoquinoline (10.0 g) isopropenyl acetate (7.2 g) and ethyl acetate (150 ml) was heated under reflux for 24 hours. The cooled, filtered solution was evaporated under reduced pressure to a small volume. The residual oil was purified by elution from a silica column with ethyl acetate/methanol mixtures followed by crystallisation from ethyl acetate to give 2-acetyl-5-amino-1,2,3,4-tetrahydroisoquinoline as a white solid 6.6 g, m.p. 107°-108° C.

1. temperaturewas heated
2. temperatureunder reflux for 24 hours
3. filtrationThe cooled, filtered solution
4. customwas evaporated under reduced pressure to a small volume
5. customThe residual oil was purified by elution from a silica column with ethyl acetate/methanol
6. custommixtures followed by crystallisation from ethyl acetate