HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Phenylsulphonamido-1,2,3,4-tetrahydroisoquinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Acetyl-5-phenylsulphonamido-1,2,3,4-tetrahydroisoquinoline | HCID 21271724 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 5-Phenylsulphonamido-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 21271748 | — |
Reaction Steps
A stirred mixture of 2-acetyl-5-phenylsulphonamido-1,2,3,4-tetrahydroisoquinoline (9.4 g), hydrochloric acid (140 ml, 3.0M) and n-butanol (14 ml) was heated under reflux for 6 hours. The solvents were evaporated under reduced pressure and the residue was recrystallised from ethanol to give 5-phenylsulphonamido-1,2,3,4-tetrahydroisoquinoline hydrochloride as a white solid (7.8 g) m.p. 209°-21° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04812573 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-775b54dbf1b04ac68ae0cb73d7db5c82 |
| Source note | uspto-grants-1989_03 |