反应详情

A stirred mixture of 2-acetyl-5-phenylsulphonamido-1,2,3,4-tetrahydroisoquinoline (9.4 g), hydrochloric acid (140 ml, 3.0M) and n-butanol (14 ml) was heated under reflux for 6 hours. The solvents were evaporated under reduced pressure and the residue was recrystallised from ethanol to give 5-phenylsulphonamido-1,2,3,4-tetrahydroisoquinoline hydrochloride as a white solid (7.8 g) m.p. 209°-21° C.

1. temperaturewas heated
2. temperatureunder reflux for 6 hours
3. customThe solvents were evaporated under reduced pressure
4. customthe residue was recrystallised from ethanol