反应详情

Formaldehyde solution (20%) (50 g) was added dropwise with stirring to 3-methoxyphenethylamine (50 g, 0.33M) over 15 minutes. The reaction was then heated for 1 hour on a steam bath. Excess concentrated hydrochloric acid was added and the mixture was then evaporated to dryness in vacuo. The residual solid was recrystallised from MeOH:isopropanol:ether to yield 6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (41 g, 61%), m.p. 234°-5° C. (lit.* 233°-4° C.).

1. temperatureThe reaction was then heated for 1 hour on a steam bath
2. customthe mixture was then evaporated to dryness in vacuo
3. customThe residual solid was recrystallised from MeOH