反应详情

6-Methoxyisoquinoline (16 g, 0.1M) and 48% aqueous HBr (600 ml) were refluxed together for 6 hours and the mixture was then evaporated to dryness in vacuo. The residue was dissolved in H2O and basified with solid Na2CO3. The resulting precipitated solid was filtered off and recrystallised from isopropanol to give 6-hydroxyisoquinoline (12 g, 82%), m.p. 218°-20° C. (lit.* 220° C.).

1. customthe mixture was then evaporated to dryness in vacuo
2. dissolutionThe residue was dissolved in H2O and basified with solid Na2CO3
3. customThe resulting precipitated solid
4. filtrationwas filtered off
5. customrecrystallised from isopropanol