反应详情

温度

50 °C

In 50 ml of toluene were dissolved 6.51 g (0.05 mole) of heptanoic acid and 10.26 g (0.06 mole) of monochloroacetic anhydride. To the resulting solution were added 4.43 g (0.065 mole) of furan and 0.71 g of boron trifluoride-diethyl ether complex and the resulting mixture was then stirred at 50° C. for 5.5 hours. After completion of the reaction, the reaction solution was cooled and washed with 5% aqueous sodium carbonate solution and water in this order. The organic layer was concentrated under reduced pressure and the resulting concentrated residue was then purified by silica gel-filled column chromatography to obtain 8.2 g of 2-heptanoylfuran.

1. customAfter completion of the reaction
2. temperaturethe reaction solution was cooled
3. washwashed with 5% aqueous sodium carbonate solution and water in this order
4. concentrationThe organic layer was concentrated under reduced pressure
5. customthe resulting concentrated residue was then purified by silica gel-
6. additionfilled column chromatography