反应详情

A suspension of 0.5 g of the product from Example 269, methanol (50 mL) and 1N sodium hydroxide (10 mL) is heated on a steam bath for 15 min. The resulting solution is cooled in an ice bath and treated with 1N hydrochloric acid (10 mL) to precipitate the product. Filtration and trituration of the damp cake with methanol (2 mL) gives pure product; mp 192°-194° C. (dec).

1. temperatureis heated on a steam bath for 15 min
2. temperatureThe resulting solution is cooled in an ice bath
3. customto precipitate the product
4. filtrationFiltration and trituration of the damp cake with methanol (2 mL)
5. customgives pure product