Hydrochloric Acid → HCID 14457643, compound

HRID 1194157Notes

Reaction equation

HRID 1194157 reaction equation
[C:1]([C:9]1[N:25]([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:12]2[CH2:13][CH:14]3[C:19](=[O:20])[N:18]([CH:21]([CH3:23])[CH3:22])[C:17](=[O:24])[N:15]3[CH2:16][C:11]=2[N:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:33].[Na+].Cl>CO>[C:1]([C:9]1[N:25]([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:12]2[CH2:13][CH:14]([C:19]([OH:20])=[O:33])[N:15]([C:17]([NH:18][CH:21]([CH3:22])[CH3:23])=[O:24])[CH2:16][C:11]=2[N:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14403755HCID 14403755, compound

Product 1

HCID 14457643HCID 14457643, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 0.5 g of the product from Example 269, methanol (50 mL) and 1N sodium hydroxide (10 mL) is heated on a steam bath for 15 min. The resulting solution is cooled in an ice bath and treated with 1N hydrochloric acid (10 mL) to precipitate the product. Filtration and trituration of the damp cake with methanol (2 mL) gives pure product; mp 192°-194° C. (dec).

Workup

  1. temperatureis heated on a steam bath for 15 min
  2. temperatureThe resulting solution is cooled in an ice bath
  3. customto precipitate the product
  4. filtrationFiltration and trituration of the damp cake with methanol (2 mL)
  5. customgives pure product

Sources & evidence

ORD record
ord-5aa1fe720a4d4ae895a938c4152f289a
Source dataset
uspto-grants-1989_03
Patent number
US04812462

Reaction notes

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