Methyl iodide → HCID 86742804, compound

HRID 1194273Notes

Reaction equation

HRID 1194273 reaction equation
[CH3:1][C@H:2]1[CH2:7][C@H:6]([N:8]2[C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][N:10]=[CH:9]2)[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[O:3]1.[I:21][CH3:22]>ClCCl>[I-:21].[CH3:1][C@H:2]1[CH2:7][C@H:6]([NH+:8]2[C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][N:10]([CH3:22])[CH2:9]2)[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[O:3]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 70378637HCID 70378637, compound

Product 1

HCID 86742804HCID 86742804, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4.2 parts of methyl trans-1-(2,3-dihydro-2-methyl-4H-1-benzopyran-4-yl)-1H-imidazole-5-carboxylate and 12 parts of iodomethane in 65 parts of dichloromethane is stirred for 20 hours at room temperature. The reaction mixture is evaporated and the residue is crystallized twice from 2,2'-oxybispropane. The product is filtered off and dried, yielding trans-1-(2,3-dihydro-2-methyl-4H-1-benzopyran-4-yl)-5-(methoxycarbonyl)-3-methyl-1H-imidazolium iodide (compound 7.04).

Workup

  1. customThe reaction mixture is evaporated
  2. customthe residue is crystallized twice from 2,2'-oxybispropane
  3. filtrationThe product is filtered off
  4. customdried

Sources & evidence

ORD record
ord-d777c67b966441acbfa4af8c5d33a86b
Source dataset
uspto-grants-1989_03
Patent number
US04813998

Reaction notes

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