反应详情

Calcium citrate with excess citric acid was prepared as follows. Specific amounts of calcium carbonate and citric acid at a molar ratio of 3:2 (i.e., 1.5) were thoroughly mixed. Warm water (50° C.-80° C.) was gradually added with agitation to form a hydrated mixture cnntaining about 40 weight percent water. Agitation was continued until CO2 evolution had apparently ceased. Additional amounts of citric acid were then added and thoroughly mixed to produce the calcium/citrate molar ratios shown in Table 4 (Example 12). The tricalcium dicitrate and tricalcium dicitrate-citric acid compositions were then dried at 60° C. to 80° C. to a moisture content of less than about 5 weight percent.

1. customto form a hydrated mixture
2. additionthoroughly mixed