Hydrochloric Acid → HCID 178517150, compound

HRID 1194292Notes

Reaction equation

HRID 1194292 reaction equation
CS[C:3]1[N:4]=[C:5]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=[C:6]2[N:7]=1.Cl.C([OH:16])C>>[OH:16][C:3]1[N:4]=[C:5]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=[C:6]2[N:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 151230382-Methylthiocycloheptimidazole

Product 1

HCID 178517150HCID 178517150, compound

Procedure

First, 60 g of 2-methylthiocycloheptimidazole as synthesized according to Synthetic example 1 (c) with reference to the method disclosed in Journal of the American Chemical Society, vol. 76, pages 3352 and 3353 (1954) was added to 300 ml of concentrated hydrochloric acid (hydrogen chloride 35%), and refluxed with heating for 2 hours and 30 minutes. Then, 500 ml of ethanol was added, and after stirring at room temperature, deposited crystals were collected by filtration. The crystals were dissolved in 0.5 of water, and pH was adjusted to around 7 with sodium bicarbonate. Deposited crystals were collected by filtration, washed with water and dried.

Workup

  1. temperaturerefluxed
  2. temperaturewith heating for 2 hours and 30 minutes
  3. filtrationwere collected by filtration
  4. dissolutionThe crystals were dissolved in 0.5 of water, and pH
  5. filtrationDeposited crystals were collected by filtration
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-62b04127d9264d748c6decc28bc16143
Source dataset
uspto-grants-1989_03
Patent number
US04814265

Reaction notes

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