Sodium Hydroxide → HCID 14458448, compound

HRID 1194301Notes

Reaction equation

HRID 1194301 reaction equation
[OH-].[Na+].C([O:5][C:6]([CH:8]1[S:17][CH2:16][S:15][CH2:14][C:9]21[O:13][CH2:12][CH2:11][O:10]2)=[O:7])C>O.C(O)C>[O:10]1[C:9]2([CH2:14][S:15][CH2:16][S:17][CH:8]2[C:6]([OH:7])=[O:5])[O:13][CH2:12][CH2:11]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 14458447HCID 14458447, compound

Product 1

HCID 14458448HCID 14458448, compoundYield 93.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 0.4 g (0.010 mole) of sodium hydroxide in 15 ml of water and 10 ml of ethanol was added 1.2 g (0.0048 mole) of 6-ethoxycarbonyl-1,4-dioxa-7,9-dithiaspiro[4.5]decane. The reaction mixture was stirred at 60° C. for six hours. After distilling off the ethanol, the mixture was cooled in an ice/water bath. The solution was acidified with concentrated hydrochloric acid, causing a white solid to precipitate. The solid was collected by filtration, washed with water, and dried in a vacuum dessicator, yielding 1.0 g of 1,4-dioxa-7,9-dithiaspiro[4.5]decane-6-carboxylic acid as a whitish solid, m.p. 195°-197° C.

Workup

  1. distillationAfter distilling off the ethanol
  2. temperaturethe mixture was cooled in an ice/water bath
  3. customto precipitate
  4. filtrationThe solid was collected by filtration
  5. washwashed with water
  6. customdried in a vacuum dessicator

Sources & evidence

ORD record
ord-1da3cf9009364d3690e059715771877f
Source dataset
uspto-grants-1989_03
Patent number
US04814325

Reaction notes

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