Potassium thiocyanate → HCID 14256955, compound

HRID 1194309Notes

Reaction equation

HRID 1194309 reaction equation
[Cl:1][C:2]1[C:3](I)=[N:4][C:5]([I:8])=[N:6][CH:7]=1.[S-:10][C:11]#[N:12].[K+]>C(O)=O>[Cl:1][C:2]1[C:3]([S:10][C:11]#[N:12])=[N:4][C:5]([I:8])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 14407714HCID 14407714, compound

Product 1

HCID 14256955HCID 14256955, compoundYield 62.5%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

In 100 ml of formic acid, a reaction of 18.4 g of 5-chloro-2,4-diiodopyrimidine and 6.0 g of potassium thiocyanate was conducted at 60° C. for 1 hour in a similar manner as Synthesis Example 1. Then, the reaction mixture was treated in a similar procedure as Synthesis Example 1, there was obtained a 62.5% yield of 5-chloro-2-iodo-4-thiocyanopyrimidine, m.p. 183°-186° C.

Workup

  1. customwas conducted at 60° C. for 1 hour in a similar manner as Synthesis Example 1
  2. additionThen, the reaction mixture was treated in a similar procedure as Synthesis Example 1

Sources & evidence

ORD record
ord-fbd3ae9040be48789272ad5d60de1890
Source dataset
uspto-grants-1989_03
Patent number
US04814337

Reaction notes

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