HCID 15615543, compound → HCID 178419539, compound

HRID 1194324Notes

Reaction equation

HRID 1194324 reaction equation
[CH3:1][N:2]([CH3:14])[C:3]([C:5]1[O:6][C:7]([C:10](=O)[CH2:11][Br:12])=[CH:8][CH:9]=1)=[O:4].[CH2:15]([NH:21][C:22]([NH:24][C:25]([NH2:27])=[S:26])=[NH:23])[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>CC(C)=O>[BrH:12].[CH2:15]([NH:21][C:22](=[NH:23])[NH:24][C:25]1[S:26][CH:11]=[C:10]([C:7]2[O:6][C:5]([C:3](=[O:4])[N:2]([CH3:14])[CH3:1])=[CH:9][CH:8]=2)[N:27]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

Participants

4

Reactant 2

HCID 15615543HCID 15615543, compoundHCID 178444831HCID 178444831, compound

Product 1

HCID 178419539HCID 178419539, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 2.6 g. (0.01 mole) of N,N-dimethyl5-(2-bromoacetyl)furan-2-carboxamide, 2.02 g. (0.01 mole) of (N-n-hexylguanyl)thiourea and 75 ml. of acetone was heated under reflux for 4 hours, and then it was cooled and filtered. This gave 2.3 g. of the title compound as a white solid, mp. 155°-158° C.

Workup

  1. additionA mixture of 2.6 g
  2. temperatureunder reflux for 4 hours
  3. temperatureit was cooled
  4. filtrationfiltered

Sources & evidence

ORD record
ord-c7d10af5220840258b44d89d8fd4d8f6
Source dataset
uspto-grants-1989_03
Patent number
US04814341

Reaction notes

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