Ethanol → HCID 21269538, compound

HRID 1194337Notes

Reaction equation

HRID 1194337 reaction equation
[CH2:1]([C:8]1[CH:17]=[CH:16][C:11]2[NH:12][C:13](=[S:15])[NH:14][C:10]=2[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:19][CH2:20][CH2:21][OH:22].[OH-].[Na+].C(O)C>O>[CH2:1]([C:8]1[CH:17]=[CH:16][C:11]2[N:12]=[C:13]([S:15][CH2:19][CH2:20][CH2:21][OH:22])[NH:14][C:10]=2[CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 123133-Chloro-1-propanolHCID 14798Sodium HydroxideHCID 21269540HCID 21269540, compound

Product 1

HCID 21269538HCID 21269538, compoundYield 65.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

12.02 g (50 mmoles) of 5-benzyl-benzimidazoline-2-thione, 4.72 ml of 3-chloro-1-propanol, 2.0 g (50 mmoles) of sodium hydroxide dissolved in water and ethanol are reacted as described in the above Example. The recovering of the product is carried out similarly. 9.76 g (65.4%) of title product are obtained. M.p.: 103°-105° C.

Workup

  1. customThe recovering of the product

Sources & evidence

ORD record
ord-25af7d720ec54cc895e6159fa6fb4259
Source dataset
uspto-grants-1989_03
Patent number
US04814329

Reaction notes

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