5-methyl-1-trityl-1H-imidazole-4-carbaldehyde → HCID 14520342, compound

HRID 1194373Notes

Reaction equation

HRID 1194373 reaction equation
Br[C:2]1[C:7]2[O:8][C:9]([CH3:13])([CH3:12])[O:10][CH2:11][C:6]=2[CH:5]=[C:4]([Cl:14])[CH:3]=1.[CH3:15][C:16]1[N:20]([C:21]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:19]=[N:18][C:17]=1[CH:40]=[O:41]>>[Cl:14][C:4]1[CH:3]=[C:2]([CH:40]([C:17]2[N:18]=[CH:19][N:20]([C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:16]=2[CH3:15])[OH:41])[C:7]2[O:8][C:9]([CH3:13])([CH3:12])[O:10][CH2:11][C:6]=2[CH:5]=1

Participants

3

Reactant 2

HCID 118243385-methyl-1-trityl-1H-imidazole-4-carbaldehydeHCID 145203368-bromo-6-chloro-2,2-dimethyl-4H-1,3-benzodioxin

Product 1

HCID 14520342HCID 14520342, compoundYield 50%

Procedure

Starting from 8-bromo-6-chloro-2,2-dimethyl-4H-1,3-benzodioxin and 5-methyl-1-triphenylmethyl-1H-imidazole-4-carboxaldehyde. The addition of the organomagnesium compound is carried out at 0° C. Yield: 50% of theory;

Workup

  1. customis carried out at 0° C

Sources & evidence

ORD record
ord-12613cc0603c43bfb13a6d469555b9b6
Source dataset
uspto-grants-1989_03
Patent number
US04814343

Reaction notes

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