1-(triphenylmethyl)-1H-imidazole-4-carbaldehyde → HCID 14520346, compound

HRID 1194377Notes

Reaction equation

HRID 1194377 reaction equation
Br[C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[C:4]([CH:10]([O:12][CH3:13])[CH3:11])[C:3]=1[O:14][CH3:15].[C:16]1([C:22]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[N:23]2[CH:27]=[C:26]([CH:28]=[O:29])[N:25]=[CH:24]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH3:15][O:14][C:3]1[C:4]([CH:10]([O:12][CH3:13])[CH3:11])=[CH:5][CH:6]=[C:7]([O:8][CH3:9])[C:2]=1[CH:28]([C:26]1[N:25]=[CH:24][N:23]([C:22]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH:27]=1)[OH:29]

Participants

3

Reactant 2

HCID 6182331-(triphenylmethyl)-1H-imidazole-4-carbaldehydeHCID 14520332HCID 14520332, compound

Product 1

HCID 14520346HCID 14520346, compoundYield 49.7%

Procedure

Starting from 1-bromo-2,6-dimethoxy-3-(1-methoxyethyl)benzene and 1-triphenylmethyl-1H-imidazole-4-carboxaldehyde. The reaction product is purified by chromatography on silica (eluent: 98:2 v/v dichloromethanemethanol). Yield: 49.7% of theory; M.P.: 96°-99° C. (recrystallized from acetonitrile).

Workup

  1. customThe reaction product is purified by chromatography on silica (eluent: 98:2 v/v dichloromethanemethanol)
  2. customM.P.: 96°-99° C. (recrystallized from acetonitrile)

Sources & evidence

ORD record
ord-10065241e72a411a9a2447b622975062
Source dataset
uspto-grants-1989_03
Patent number
US04814343

Reaction notes

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