HRID1194378

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCC(=O)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1

HCID14520334

1-[1-(Triphenylmethyl)-1H-imidazol-4-yl]-1-pentanone

C27H26N2O

HCID14520336

8-Bromo-6-chloro-2,2-dimethyl-4H-1,3-benzodioxin

C10H10BrClO2

PRODUCTS

生成物

结构：CCCCC(O)(c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)c1cc(Cl)cc2c1OC(C)(C)OC2

HCID14520348

未命名化合物

收率 54.6%

PROCEDURE

实验过程

This compound is prepared like the preceding compound by reacting the organomagnesium compound of 8-bromo-6-chloro-2,2-dimethyl-4H-1,3-benzodioxin with 1-(1-triphenylmethyl-1H-imidazol-4-yl)-1-pentanone. Yield: 54.6% of theory; M.P.: 124° C. (recrystallized from petroleum ether).

WORKUP

后处理

customThis compound is prepared like the preceding compound
customM.P.: 124° C. (recrystallized from petroleum ether)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7dc5d4e89dff43ec89611a727c9cff0f
来源数据集: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04814343
来源说明: uspto-grants-1989_03

反应 SMILES

Br[C:2]1[C:7]2[O:8][C:9]([CH3:13])([CH3:12])[O:10][CH2:11][C:6]=2[CH:5]=[C:4]([Cl:14])[CH:3]=1.[C:15]1([C:21]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[N:22]2[CH:26]=[C:25]([C:27](=[O:32])[CH2:28][CH2:29][CH2:30][CH3:31])[N:24]=[CH:23]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:28]([C:27]([C:2]1[C:7]2[O:8][C:9]([CH3:13])([CH3:12])[O:10][CH2:11][C:6]=2[CH:5]=[C:4]([Cl:14])[CH:3]=1)([C:25]1[N:24]=[CH:23][N:22]([C:21]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:26]=1)[OH:32])[CH2:29][CH2:30][CH3:31]