HCID 21270012, compound → HCID 14520347, compound

HRID 1194381Notes

Reaction equation

HRID 1194381 reaction equation
[CH3:1][Mg]I.[Cl:4][C:5]1[CH:16]=[C:15]([C:17]([C:19]2[N:20]=[CH:21][N:22]([C:24]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH:23]=2)=[O:18])[C:8]2[O:9][C:10]([CH3:14])([CH3:13])[O:11][CH2:12][C:7]=2[CH:6]=1>>[Cl:4][C:5]1[CH:16]=[C:15]([C:17]([CH3:1])([C:19]2[N:20]=[CH:21][N:22]([C:24]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH:23]=2)[OH:18])[C:8]2[O:9][C:10]([CH3:13])([CH3:14])[O:11][CH2:12][C:7]=2[CH:6]=1

Participants

3

Reactant 2

HCID 21270012HCID 21270012, compoundHCID 178418373HCID 178418373, compound

Product 1

HCID 14520347HCID 14520347, compoundYield 80%

Procedure

This compound is prepared like the preceding compound starting from methyl magnesium iodide and (6-chloro-2,2-dimethyl-4H-1,3-benzodioxin-8-yl)(1-triphenylmethyl-1H-imidazol-4-yl)ketone. The residue obtained after evaporation of the dichloromethane crystallizes when stirred in diethyl ether. Yield: 80% of theory; M.P.: 182°-184° C. (recrystallized from ethyl acetate).

Workup

  1. customThis compound is prepared like the preceding compound
  2. customThe residue obtained
  3. customafter evaporation of the dichloromethane
  4. customcrystallizes when
  5. customM.P.: 182°-184° C. (recrystallized from ethyl acetate)

Sources & evidence

ORD record
ord-eb1ae821e27f469fa49170e7191da39d
Source dataset
uspto-grants-1989_03
Patent number
US04814343

Reaction notes

Loading…