Potassium Carbonate → HCID 13588739, compound

HRID 1194497Notes

Reaction equation

HRID 1194497 reaction equation
Cl.[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].Cl[C:10]1[O:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH:7][C:10]1[O:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)[CH3:3]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 119862-ChlorobenzoxazoleHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 13588739HCID 13588739, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

22.3 g (0.16 mole) of glycine ethyl ester hydrochloride were stirred in small portions into a mixture of 23.0 g (0.15 mole) of 2-chlorobenzoxazole, 250 ml of absolute acetonitrile and 44.2 g (0.32 mole) of anhydrous K2CO3 at 50° C. in the course of 3 hours, with stirring. The mixture was subsequently stirred under gentle reflux (80°-82° C.) for a further 4 hours, cooled in an ice-water bath and poured into about 750 ml of ice-water.

Workup

  1. stirringThe mixture was subsequently stirred
  2. temperatureunder gentle reflux (80°-82° C.) for a further 4 hours
  3. temperaturecooled in an ice-water bath

Sources & evidence

ORD record
ord-bc0c5bdb5e644f079c9dd1ed971c222c
Source dataset
uspto-grants-1989_03
Patent number
US04814459

Reaction notes

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