HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1194575Generated: October 31, 2026
Thionyl Chloride → (S)-(-)-(3-Chloro-2-hydroxypropyl)trimethylammonium chloride
https://huagongshe.com/reaction/1194575
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (S)-2,3-Dihydroxy-N,N,N-trimethylpropan-1-aminium chloride | HCID 13668848 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (S)-(-)-(3-Chloro-2-hydroxypropyl)trimethylammonium chloride | HCID 2793814 | 88.8% |
Reaction Steps
There was suspended 10.73 g of the obtained (S)-2,3-dihydroxypropyltrimethylammonium chloride in 50 ml of dimethylformamide, and then 7.66 g of thionyl chloride was added thereto at a temperature from 5° to 10° C. After stirring for 20 minutes, it was heated for 5 hours at 100° C. After cooling the reaction mixture to room temperature, the reaction mixture was evaporated to dryness to give 10.56 g of (S)-3-chloro-2-hydroxypropyltrimethylammonium chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04814506 |
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| Source dataset | uspto-grants-1989_03 |
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| ORD ID | ord-3a13b6f681504a1abfc56d666c545c97 |
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| Source note | uspto-grants-1989_03 |
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