反应详情

温度

100 °C

There was suspended 10.73 g of the obtained (S)-2,3-dihydroxypropyltrimethylammonium chloride in 50 ml of dimethylformamide, and then 7.66 g of thionyl chloride was added thereto at a temperature from 5° to 10° C. After stirring for 20 minutes, it was heated for 5 hours at 100° C. After cooling the reaction mixture to room temperature, the reaction mixture was evaporated to dryness to give 10.56 g of (S)-3-chloro-2-hydroxypropyltrimethylammonium chloride.

1. customfrom 5° to 10° C
2. temperatureAfter cooling the reaction mixture to room temperature
3. customthe reaction mixture was evaporated to dryness