反应详情

温度

100 °C

Moreover, the obtained (S)-2,3-dihydroxypropyltrimethylammonium chloride was suspended in 100 ml of dimethylformamide and then 22.57 g of thionyl chloride was added thereto at a tempareture from 5° to 10° C. After stirring for 20 minutes, it was heated for 5 hours at 100° C. Finally, after the reaction was completed and the reaction mixture was cooled to room temperature, it was evaporated to dryness and then the residue was washed with methylene chloride to give 30.20 g of (S)-3-chloro-2-hydroxypropyltrimethylammonium chloride.

1. customfrom 5° to 10° C
2. temperaturethe reaction mixture was cooled to room temperature
3. customit was evaporated to dryness
4. washthe residue was washed with methylene chloride