Thionyl Chloride → HCID 19817494, compound

HRID 1194613Notes

Reaction equation

HRID 1194613 reaction equation
[ClH:1].[N:2]1([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.S(Cl)([Cl:16])=O>>[ClH:16].[N:2]1([CH2:8][CH2:9][CH2:10][C:11]([Cl:1])=[O:13])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 131720814-(Piperidin-1-yl)butanoic acid hydrochloride

Product 1

HCID 19817494HCID 19817494, compound

Procedure

4-Piperidinobutyric acid hydrochloride (750 mg) and 4 ml of thionyl chloride were combined and stirred at reflux for 45 min., concentrated, triturated with ether and dried to give 700 mg of light brown solid which when dissolved in dry methanol gave Rf 0.1 in system D, distinctly different from the starting acid and presumably the methyl ester. The solid was used without further purification.

Workup

  1. temperatureat reflux for 45 min.
  2. concentrationconcentrated
  3. customtriturated with ether
  4. customdried

Sources & evidence

ORD record
ord-45d64b97c4ee4d46ad32035e9aa75c02
Source dataset
uspto-grants-1989_03
Patent number
US04814342

Reaction notes

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