Propargyl bromide → HCID 19987015, compound

HRID 1194629Notes

Reaction equation

HRID 1194629 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]2[N:17]3[N:12]([CH2:13][CH2:14][CH2:15][CH2:16]3)[C:11](=[O:18])[S:10]2)=[C:4]([F:19])[C:3]=1[OH:20].[CH2:21](Br)[C:22]#[CH:23].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]2[N:17]3[N:12]([CH2:13][CH2:14][CH2:15][CH2:16]3)[C:11](=[O:18])[S:10]2)=[C:4]([F:19])[C:3]=1[O:20][CH2:23][C:22]#[CH:21]

Participants

5

Reactant 3

HCID 7842Propargyl bromideHCID 11430Potassium CarbonateHCID 19987013HCID 19987013, compound

Product 1

HCID 19987015HCID 19987015, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Into a reaction flask equipped with a Dimroth condenser, 2.2 g (7 mmol) of 9-(4-chloro-2-fluoro-3-hydroxyphenylimino)-8-thia-1,6-diazabicyclo[4.3.0]nonane-7-one, 1.1 g (9 mmol) of propargyl bromide, 1.3 g (9 mmol) of potassium carbonate and 20 ml of acetonitrile, were charged, and refluxed under heating for 3 hours to complete the reaction.

Workup

  1. additionwere charged
  2. temperaturerefluxed
  3. temperatureunder heating for 3 hours
  4. customthe reaction

Sources & evidence

ORD record
ord-3b7a465767424f4099d0c122fbd507ba
Source dataset
uspto-grants-1989_03
Patent number
US04816063

Reaction notes

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