HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 3,4-Difluoro-4'-methoxy-1,1'-biphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1,2-Difluoro-4-iodobenzene | HCID 2724444 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | 3,4-Difluoro-4'-methoxy-1,1'-biphenyl | HCID 15312136 | — |
Reaction Steps
A p-methoxyphenylmagnesium halide as a Grignard reagent, obtained from a p-halogenoanisole (IV), is reacted with a 3,4-difluoro-1-iodobenzene (V) at a low temperature in the vicinity of 0° C. in an ether solvent in the presence of Ni catalyst to obtain a 3,4-difluoro-4'-methoxybiphenyl (VI), which is then reacted with HBr to obtain (III). These reactions are expressed by the following reaction equations: ##STR6##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04816179 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-f1c7ae5af65546749979da8b149efa10 |
| Source note | uspto-grants-1989_03 |