反应详情

4-(4'-Trifluoromethylphenoxy)phenyl isocyanate (3.7 g.) was added to a stirred mixture of 1,3-dimethyl-2-thiobarbituric acid (2.3 g.) and triethylamine (1.7 ml.) in dry benzene (30 ml.). The mixture was refluxed for 12 hours. The mixture was evaporated in vacuo. Diethyl ether (10 ml.) was added to the gummy residue and the mixture was acidified with 1N hydrochloric acid. The mixture was filtered and the solid was washed with water and then ethanol.

1. temperatureThe mixture was refluxed for 12 hours
2. customThe mixture was evaporated in vacuo
3. additionDiethyl ether (10 ml.) was added to the gummy residue
4. filtrationThe mixture was filtered
5. washthe solid was washed with water