Hydrazine hydrate (1:1) → HCID 13592810, compound

HRID 1194668Notes

Reaction equation

HRID 1194668 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:12]=[CH:11][C:10]([C:13](=O)[CH2:14][CH2:15][C:16]([OH:18])=O)=[CH:9][CH:8]=1.O.[NH2:21][NH2:22]>C(O)C>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH2:14][CH2:15][C:16](=[O:18])[NH:21][N:22]=2)=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21249140HCID 21249140, compound

Product 1

HCID 13592810HCID 13592810, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.4 g (0.04 mole) of 4-(4-(2-oxo-pyrrolidin-1-yl)-phenyl)-4-oxo-butyric acid and 2 g (0.04 mole) of hydrazine hydrate are stirred under reflux in 100 ml of ethanol for 1 hour, the mixture is cooled and the product is filtered off with suction. The solid which has precipitated is stirred with sodium bicarbonate solution, filtered off with suction, washed and dried.

Workup

  1. temperaturethe mixture is cooled
  2. filtrationthe product is filtered off with suction
  3. customThe solid which has precipitated
  4. filtrationfiltered off with suction
  5. washwashed
  6. customdried

Sources & evidence

ORD record
ord-8dfdb979efa440018d6003ce2901c16b
Source dataset
uspto-grants-1989_03
Patent number
US04816454

Reaction notes

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