Ethanol → HCID 178433858, compound

HRID 1194671Notes

Reaction equation

HRID 1194671 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([CH3:13])[C:3]=1[C:14](=O)[CH:15]([CH3:20])[CH2:16]C(O)=O.O.[NH2:23][NH2:24].[CH2:25]([OH:27])C>>[OH:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:5]=[C:4]([CH3:13])[C:3]=1[CH:14]1[CH:15]([CH3:20])[CH:16]=[N:24][NH:23][C:25]1=[O:27]

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 178433861HCID 178433861, compound

Product 1

HCID 178433858HCID 178433858, compound

Procedure

4.5 g (0.016 mole) of 4-(4-(5-hydroxy-3-methyl-1-phenylpyrazolyl)-4-oxo-3-methyl-butyric acid and 1.5 ml (0.031 mole) of hydrazine hydrate are heated under reflux in 30 ml of ethanol for 1 hour. After the mixture has been concentrated, the residue is boiled up with isopropanol, the mixture is filtered and the product which has crystallised out is separated off.

Workup

  1. concentrationAfter the mixture has been concentrated
  2. filtrationthe mixture is filtered
  3. customthe product which has crystallised out
  4. customis separated off

Sources & evidence

ORD record
ord-1872d9ba09824ccbbeeabb19dbc01197
Source dataset
uspto-grants-1989_03
Patent number
US04816454

Reaction notes

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