Hydrazine hydrate (1:1) → HCID 21249138, compound

HRID 1194672Notes

Reaction equation

HRID 1194672 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13](=O)[CH:14]([CH3:19])[CH2:15][C:16](O)=[O:17])=[C:9]([O:21][CH3:22])[CH:8]=2)=[N:4][N:3]=1.O.[NH2:24][NH2:25]>C(O)C>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13]3[CH:14]([CH3:19])[CH2:15][C:16](=[O:17])[NH:24][N:25]=3)=[C:9]([O:21][CH3:22])[CH:8]=2)=[N:4][N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21249114HCID 21249114, compound

Product 1

HCID 21249138HCID 21249138, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.1 g (0.033 mole) of 4-(4-(5-methyl-1,3,4-oxadiazol-2-yl)-methoxy-phenyl)-4-oxo-3-methyl-butyric acid and 2.1 ml (0.043 mole) of hydrazine hydrate are stirred in 100 ml of ethanol at 50° C. for 1 hour. After addition of a mixture of diethyl ether/ligroin until cloudiness results, the product crystallises out. After filtering off with suction, the product is recrystallised from 500 ml of isopropanol.

Workup

  1. customresults
  2. customthe product crystallises out
  3. filtrationAfter filtering off with suction
  4. customthe product is recrystallised from 500 ml of isopropanol

Sources & evidence

ORD record
ord-5c9abdadab5b450ba6899b989115c425
Source dataset
uspto-grants-1989_03
Patent number
US04816454

Reaction notes

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