p-Chlorophenoxyacetyl chloride → HCID 13749454, compound

HRID 1194678Notes

Reaction equation

HRID 1194678 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8](Cl)=[O:9])=[CH:4][CH:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]([CH3:27])[CH2:22][C:23](=[O:26])[NH:24][N:25]=2)=[CH:16][CH:15]=1>CN(C)C1C=CN=CC=1.N1C=CC=CC=1>[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]([CH3:27])[CH2:22][C:23](=[O:26])[NH:24][N:25]=3)=[CH:16][CH:15]=2)=[O:9])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 77771p-Chlorophenoxyacetyl chlorideHCID 161928Ici 109,081

Product 1

HCID 13749454HCID 13749454, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 1049PyridineSolvent

Procedure

0.1 g of 4-dimethylaminopyridine and 5.1 g (0.025 mole) of 4-chlorophenoxyacetyl chloride are added to 5.1 g (0.025 mole) of 6-(4-amino-phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone in 20 ml of pyridine. The mixture is stirred at room temperature for 5 hours and concentrated, water is added and the mixture is extracted with methylene chloride.

Workup

  1. concentrationconcentrated
  2. additionwater is added
  3. extractionthe mixture is extracted with methylene chloride

Sources & evidence

ORD record
ord-c27eeb1825064104a525eeff12ce58c0
Source dataset
uspto-grants-1989_03
Patent number
US04816454

Reaction notes

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