Phenol → HCID 12233753, compound

HRID 1194694Notes

Reaction equation

HRID 1194694 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]2=[N:6][C:7]3[CH2:8][CH2:9][N:10]([CH3:15])[CH2:11][C:12]=3[C:13](Cl)=[C:4]2[CH:3]=1.C1(O)C=CC=CC=1.[NH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[OH-].[K+]>C(OCC)C>[NH:25]([C:13]1[C:12]2[CH2:11][N:10]([CH3:15])[CH2:9][CH2:8][C:7]=2[N:6]=[C:5]2[CH:16]=[CH:17][C:2]([Cl:1])=[CH:3][C:4]=12)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

6

Reactant 4

HCID 996PhenolHCID 6115AnilineHCID 14797Potassium HydroxideHCID 12273863HCID 12273863, compound

Product 1

HCID 12233753HCID 12233753, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

By the method described for Example 14, a mixture of the compound of Example 6 (15.0 g, 0.0562 mol), 10.69 (0.115 mol) of phenol and 10.3 mol (0.115 mol) of aniline is reacted. Thereafter, the reaction mixture is slurried with a mixture of 10% aqueous potassium hydroxide and diethyl ether. The insoluble product is filtered and recrystallized from acetonitrile giving the title compound (13.0 g, 72%), m.p. 137°-139° C.

Workup

  1. customis reacted
  2. filtrationThe insoluble product is filtered
  3. customrecrystallized from acetonitrile giving the title compound (13.0 g, 72%), m.p. 137°-139° C.

Sources & evidence

ORD record
ord-e018674de04e44a68d1324a258213ec8
Source dataset
uspto-grants-1989_03
Patent number
US04816464

Reaction notes

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