Methoxyacetyl chloride → HCID 136336892, compound

HRID 1194803Notes

Reaction equation

HRID 1194803 reaction equation
COCC(Cl)=O.[O:7]([CH2:14][C:15]([O:17][CH2:18][CH:19]([O:32][CH2:33][N:34]1[CH:42]=[N:41][C:40]2[C:39](=[O:43])[NH:38][C:37]([NH2:44])=[N:36][C:35]1=2)[CH2:20][O:21][C:22](=[O:31])[CH2:23][O:24][C:25]1C=CC=CC=1)=[O:16])[C:8]1C=CC=CC=1>>[CH3:25][O:24][CH2:23][C:22]([O:21][CH2:20][CH:19]([O:32][CH2:33][N:34]1[CH:42]=[N:41][C:40]2[C:39](=[O:43])[NH:38][C:37]([NH2:44])=[N:36][C:35]1=2)[CH2:18][O:17][C:15](=[O:16])[CH2:14][O:7][CH3:8])=[O:31]

Participants

3

Reactant 2

HCID 96623Methoxyacetyl chlorideHCID 136336893HCID 136336893, compound

Product 1

HCID 136336892HCID 136336892, compound

Procedure

Reaction of hydrated 9-(1,3-dihydroxy-2-propoxymethyl)guanine (1 mmole) with methoxyacetyl chloride (4 mmole) according to the method used for 9-[1,3-bis(phenoxyacetoxy)-2-propoxymethyl]guanine (Example 14) gives, after chromatography, the desired product. Confirmation of structure and purity are obtained by NMR and TLC (9:1CHCl3 --MeOH).

Workup

  1. customgives

Sources & evidence

ORD record
ord-1403ea548bdc4cad988f3e156e27e9c5
Source dataset
uspto-grants-1989_03
Patent number
US04816447

Reaction notes

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