Water → HCID 21268593, compound

HRID 1194820Notes

Reaction equation

HRID 1194820 reaction equation
C[O:2][C:3]1[C:11]([CH2:12][C:13]([OH:15])=[O:14])=[CH:10][C:6]2[CH:7]=[CH:8][O:9][C:5]=2[C:4]=1[C:16](=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.O>C(O)(=O)C.Br>[OH:2][C:3]1[C:11]([CH2:12][C:13]([OH:15])=[O:14])=[CH:10][C:6]2[CH:7]=[CH:8][O:9][C:5]=2[C:4]=1[C:16](=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

5

Reactant 2

HCID 962WaterHCID 21268645HCID 21268645, compound

Product 1

HCID 21268593HCID 21268593, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

6-Methoxy-7-benzoylbenzofuran-5-ylacetic acid (5.0 g) was heated at reflux in a mixture of acetic acid (50 ml) and 48% hydrobromic acid (50 ml). After the reaction was completed, approximately 1 hour, the cooled solution was added to 400 ml of water which was then extracted with ethyl acetate. The combined organic extracts were washed four times with water, dried with sodium sulfate and evaporated to give 6-hydroxy-7-benzoylbenzofuran-5-ylacetic acid.

Workup

  1. extractionwas then extracted with ethyl acetate
  2. washThe combined organic extracts were washed four times with water
  3. dry with materialdried with sodium sulfate
  4. customevaporated

Sources & evidence

ORD record
ord-7bd9030e15fc4701b38e5f0f5f2048ce
Source dataset
uspto-grants-1989_03
Patent number
US04816473

Reaction notes

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