Calcium Carbonate → HCID 70353199, compound

HRID 1194824Notes

Reaction equation

HRID 1194824 reaction equation
[C:1]([C:9]1[C:17]2[O:16][CH:15]=[CH:14][C:13]=2[CH:12]=[C:11]([CH2:18][C:19]([OH:21])=[O:20])[CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].[C:24]([C:32]1[C:40]2[O:39][CH:38]=[CH:37][C:36]=2[CH:35]=[C:34]([CH2:41][C:42]([O-:44])=[O:43])[CH:33]=1)(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[K+].C(=O)([O-])[O-].[Ca+2:50].[Cl-].[NH4+].[Ca]>CO.Cl.O>[C:1]([C:9]1[C:17]2[O:16][CH:15]=[CH:14][C:13]=2[CH:12]=[C:11]([CH2:18][C:19]([O-:21])=[O:20])[CH:10]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[Ca+2:50].[C:24]([C:32]1[C:40]2[O:39][CH:38]=[CH:37][C:36]=2[CH:35]=[C:34]([CH2:41][C:42]([O-:44])=[O:43])[CH:33]=1)(=[O:31])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

10

Reactant 6

HCID 10112Calcium Carbonate2×HCID 14797Potassium HydroxideHCID 25517Ammonium ChlorideHCID 5460341CalciumHCID 137043977-Benzoyl-5-benzofuranacetic acidHCID 23699967HCID 23699967, compound2×

Product 1

HCID 70353199HCID 70353199, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 200 mg of 7-benzoylbenzofuran-5-ylacetic acid in 5 ml of methanol is added a 1 molar equivalent of potassium hydroxide in the form of a 0.1 N solution, thus, yielding a solution containing potassium 7-benzoylbenzofuran-5-ylacetate. A solution of 60 mg of calcium carbonate dissolved in the minimum amount of 1 N hydrochloric acid necessary to effect solution of the calcium carbonate is bufered with 150 mg of solid ammonium chloride followed by the addition of 5 ml of water. The thus obtained buffered calcium solution is then added to the solution of potassium 7-benzoylbenzofuran-5-ylacetate and the precipitate which forms is collected by filtration, washed with water and air dried to yield calcium 7-benzoylbenzofuran-5-ylacetate.

Workup

  1. customthus, yielding a solution
  2. customThe thus obtained
  3. filtrationthe precipitate which forms is collected by filtration
  4. washwashed with water and air
  5. customdried

Sources & evidence

ORD record
ord-bab880af62dc4732a828fb1c872aae42
Source dataset
uspto-grants-1989_03
Patent number
US04816473

Reaction notes

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