HRID1194880

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6555

1-Bromo-2-methylpropane

C4H9Br

$结构：CCOC(=O)/C(=N\O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.Cl$

HCID9589415

(Z)-Ethyl 2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate hydrochloride

C26H24ClN3O3S

PRODUCTS

生成物

$结构：CCOC(=O)/C(=N\OCC(C)C)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1$

HCID140352835

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Ethyl (Z)-2-(hydroxyimino)-2-(2-tritylaminothiazol-4-yl)acetate hydrochloride (1 g) was alkylated with 1-bromo-2-methylpropane (0.48 ml) as described in Example 5a to give the title compound (0.8 g), νmax (CHCl3) 3400, 2960, 1725, 1520 and 1025 cm-1 m; δH (CDCl3) 1.09 (6H, d, J 7 Hz), 1.30 (3H, t), 1.90 (1H, m), 3.95 (2H, d, J 7 Hz), 4.30 (2H, q), 6.42 (1H, s), 6.93 (1H, br.s), 7.22 (15H, m). [Mass spectrum: +ve ion (3NOBA) MH+ (514)].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-acba8d3d00b7430c8fbbd89b492400c4
来源数据集: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04816452
来源说明: uspto-grants-1989_03

反应 SMILES

Cl.[OH:2]/[N:3]=[C:4](/[C:10]1[N:11]=[C:12]([NH:15][C:16]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[S:13][CH:14]=1)\[C:5]([O:7][CH2:8][CH3:9])=[O:6].Br[CH2:36][CH:37]([CH3:39])[CH3:38]>C(Cl)(Cl)Cl>[CH3:36][CH:37]([CH3:39])[CH2:38][O:2]/[N:3]=[C:4](/[C:10]1[N:11]=[C:12]([NH:15][C:16]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[S:13][CH:14]=1)\[C:5]([O:7][CH2:8][CH3:9])=[O:6]