HRID1194891

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID137636

Cyclohexane, (bromomethyl)-

C7H13Br

$结构：CCOC(=O)/C(=N\O)c1csc(NC(c2ccccc2)(c2ccccc2)c2ccccc2)n1.Cl$

HCID9589415

(Z)-Ethyl 2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate hydrochloride

C26H24ClN3O3S

PRODUCTS

生成物

$结构：CCOC(=O)/C(=N\OCC1CCCCC1)c1csc(N)n1$

HCID14865018

未命名化合物

收率 62%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID284

Formic acid

CH2O2

PROCEDURE

实验过程

Ethyl (Z)-2-(hydroxyimino)-2-(2-tritylaminothiazol-4-yl)acetate hydrochloride (3.08 g) was reacted with cyclohexylmethyl bromide as described in Example 5a. The product was deprotected with formic acid as described in Example 1a. Crystallisation from cyclohexane/hexane gave the title compound as a white solid (1.2 g, 62%), m.p. 107.0°-107.5° C. [Found: C: 54.21; H: 6.58; N: 13.31. C14H21N3O3S requires C: 54.00; H: 6.80; N: 13.49%]. νmax (CHCl3) 3400, 2920, 1730, 1600 cm-1 ; δH (CDCl3) 1.0 (2H, m), 1.2 (3H, m), 1.33 (3H, t), 1.7 (6H, m), 3.97 (2H, d), 4.35 (2H, q), 5.60 (2H, br s, exch. D2O), 6.63 (1H, s).

WORKUP

后处理

customCrystallisation from cyclohexane/hexane