Cyclohexane, (bromomethyl)- → HCID 14865018, compound

Participants

Reaction Steps

Ethyl (Z)-2-(hydroxyimino)-2-(2-tritylaminothiazol-4-yl)acetate hydrochloride (3.08 g) was reacted with cyclohexylmethyl bromide as described in Example 5a. The product was deprotected with formic acid as described in Example 1a. Crystallisation from cyclohexane/hexane gave the title compound as a white solid (1.2 g, 62%), m.p. 107.0°-107.5° C. [Found: C: 54.21; H: 6.58; N: 13.31. C14H21N3O3S requires C: 54.00; H: 6.80; N: 13.49%]. νmax (CHCl3) 3400, 2920, 1730, 1600 cm-1 ; δH (CDCl3) 1.0 (2H, m), 1.2 (3H, m), 1.33 (3H, t), 1.7 (6H, m), 3.97 (2H, d), 4.35 (2H, q), 5.60 (2H, br s, exch. D2O), 6.63 (1H, s).

Provenance & Evidence