Chloroacetonitrile → HCID 88662945, compound
Reaction equation
[OH:1]/[N:2]=[C:3](/[C:20]1[N:21]=[C:22]([NH:25][C:26]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[S:23][CH:24]=1)\[C:4]([O:6][CH:7]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5].Cl[CH2:46][C:47]#[N:48]>>[C:47]([CH2:46][O:1]/[N:2]=[C:3](/[C:20]1[N:21]=[C:22]([NH:25][C:26]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[S:23][CH:24]=1)\[C:4]([O:6][CH:7]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:5])#[N:48]Participants
3
Procedure
Diphenylmethyl (Z)-2-hydroxyimino-2-(2-tritylaminothiazol-4-yl)acetate (1.5 g) was alkylated with chloroacetonitrile (0.38 g) as described in Example 5a to give the title compound as a white solid (1.23 g); νmax (CH2Cl2) 3400, 1740, 1535 and 1490 cm-1 ; δH (CDCl3) 4.82 (2H, s), 6.45 (1H, s), 6.98 (1H, broad s), 7.17 (1H, s) and 7.26-7.52 (25H, m). [Mass spectrum: +ve ion (3NOBA) MH+ (635) and (3NOBA/Na+) MNa+ (657)]
Sources & evidence
- ORD record
- ord-cf744a7198d9415b9d75ef994ece2f42
- Source dataset
- uspto-grants-1989_03
- Patent number
- US04816452
Reaction notes
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