Water → HCID 13589046, compound

HRID 1194895Notes

Reaction equation

HRID 1194895 reaction equation
[C:1]([CH2:3][O:4]/[N:5]=[C:6](/[C:23]1[N:24]=[C:25]([NH:28]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[S:26][CH:27]=1)\[C:7]([O:9]C(C1C=CC=CC=1)C1C=CC=CC=1)=[O:8])#[N:2].O>C(O)=O>[NH2:28][C:25]1[S:26][CH:27]=[C:23](/[C:6](=[N:5]/[O:4][CH2:3][C:1]#[N:2])/[C:7]([OH:9])=[O:8])[N:24]=1

Participants

4

Reactant 2

HCID 962WaterHCID 88662945HCID 88662945, compound

Product 1

HCID 13589046HCID 13589046, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Diphenylmethyl (Z)-2-cyanomethoxyimino-2-(2-tritylaminothiazol-4-yl)acetate (lg) was dissolved in formic acid (98%, 40 ml) and water (10 ml) at room temperature and stirred for 12 h. The solvent was removed in vacuo and the residue triturated with ether to give the title compound as an off-white solid (0.39 g). The product was sufficiently pure for the next step; νmax (nujol) 3700-2500, 1605 (broad), 1465 and 1380 cm-1 ; δH inter alia 5.09 (2H, s), 7.04 (1H, s). [Mass spectrum: EI M+ (226)].

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue triturated with ether

Sources & evidence

ORD record
ord-153cabdf02344db086a3038e37b4713e
Source dataset
uspto-grants-1989_03
Patent number
US04816452

Reaction notes

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