HCID 21248854, compound → HCID 21248864, compound

HRID 1194931Notes

Reaction equation

HRID 1194931 reaction equation
C([NH:20][C:21]1[S:22][CH:23]=[C:24](/[C:26](=[N:43]/[O:44][C:45]2([C:51]([O:53][CH2:54][C:55]3[CH:60]=[CH:59][C:58]([N+:61]([O-:63])=[O:62])=[CH:57][CH:56]=3)=[O:52])[CH2:50][CH2:49][CH2:48][CH2:47][CH2:46]2)/[C:27]([O:29]C(C2C=CC=CC=2)C2C=CC=CC=2)=[O:28])[N:25]=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(O)=O>[NH2:20][C:21]1[S:22][CH:23]=[C:24](/[C:26](=[N:43]/[O:44][C:45]2([C:51]([O:53][CH2:54][C:55]3[CH:60]=[CH:59][C:58]([N+:61]([O-:63])=[O:62])=[CH:57][CH:56]=3)=[O:52])[CH2:50][CH2:49][CH2:48][CH2:47][CH2:46]2)/[C:27]([OH:29])=[O:28])[N:25]=1

Participants

3

Reactant 1

HCID 21248854HCID 21248854, compound

Product 1

HCID 21248864HCID 21248864, compoundYield 85.3%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Benzhydryl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(1-(4-nitrobenzyl)oxycarbonylcyclohexyloxyimino)acetate (1.3 g) was treated with aqueous formic acid as described in Example 23d to give the title compound (0.58 g, 85%) as a white solid. m.p. 184°-185° C., [Found: C: 50.94; H: 4.56; N: 12.48. C19H20N4O7S requires C: 50.89; H: 4.50; N: 12.49%] νmax (KBr) 3358, 2939, 1735, 1608, 1515, and 1346 cm-1, δH (CDCl3) 1.28 (1H, m), 1.52 (5H, m), 1.78 (2H, m), 2.01 (2H, m), 5.34 (2H, s), 6.80 (1H, s), 7.31 (2H, br s), 7.63 (2H, d), and 8.13 (2H, d).

Sources & evidence

ORD record
ord-86be260a4c8c4dda83a706957a21d8ec
Source dataset
uspto-grants-1989_03
Patent number
US04816452

Reaction notes

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