Hydrochloric Acid → HCID 178512889, compound

HRID 1194987Notes

Reaction equation

HRID 1194987 reaction equation
Cl.CC(O)=O.[NH:6](C(OC(C)(C)C)=O)[C@H:7]([C:15]([NH:17][C@H:18]([C:26]([OH:28])=[O:27])[CH2:19][CH2:20][CH2:21][NH:22][C:23](=[NH:25])[NH2:24])=[O:16])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.Cl>>[NH2:6][C@H:7]([C:15]([NH:17][C@H:18]([C:26]([OH:28])=[O:27])[CH2:19][CH2:20][CH2:21][NH:22][C:23](=[NH:24])[NH2:25])=[O:16])[CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 22641269Acetate-hydrochloric acidHCID 178454153HCID 178454153, compound

Product 1

HCID 178512889HCID 178512889, compoundYield 100.1%

Procedure

Into 538 ml of 2N HCl/AcOH was dissolved 79.8 g (0.13 mole) of BOC-Phe-Arg-CHA.HCl. After reacting it at room temperature for one hour, the deposited matter was collected by filtration, washed with AcOH and ether and dried to obtain 41.8 g (58.7%) of H-Phe-Arg-CHA.2HCl.

Workup

  1. customat room temperature
  2. customfor one hour
  3. filtrationthe deposited matter was collected by filtration
  4. washwashed with AcOH and ether
  5. customdried

Sources & evidence

ORD record
ord-a5821e2ec81a48eea6dab352695b5823
Source dataset
uspto-grants-1989_03
Patent number
US04816562

Reaction notes

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