Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | HCID 18631277 | HCID 18631277 | — |
| Product | HCID 14403484 | HCID 14403484 | — |
Reaction Steps
A solution of 7.8 g 3-(2-(1-adamantyl)ethyl)histidine.2HCl in 100 mL 1N HCl is treated with 5 mL 36% formaldehyde, stirring 30 min at 25° C. followed by 90 min at reflux. Evaporation gives 1-(2-(1-adamantyl)ethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride as a white solid. NMR (D2O) 8.90 (s, 1H, 2-Im).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04816463 |
|---|
| Source dataset | uspto-grants-1989_03 |
|---|
| ORD ID | ord-6c5a8d74b9fe4423a649ecf0c6640d4c |
|---|
| Source note | uspto-grants-1989_03 |
|---|
