Potassium Hydroxide → 4-(2-Carboxybenzyloxy)phenylpropanoic acid

HRID 1195025Notes

Reaction equation

C([O:3][C:4]([C:6]1[CH:26]=[CH:25][CH:24]=[CH:23][C:7]=1[CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([CH3:22])[C:17]([O:19]CC)=[O:18])=[CH:12][CH:11]=1)=[O:5])C.[OH-].[K+]>>[C:4]([C:6]1[CH:26]=[CH:25][CH:24]=[CH:23][C:7]=1[CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([CH3:22])[C:17]([OH:19])=[O:18])=[CH:12][CH:11]=1)([OH:5])=[O:3]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 54555132Ethyl 4-(2-ethoxycarbonylbenzyloxy)-alpha-methylphenylacetate

Product 1

HCID 122923134-(2-Carboxybenzyloxy)phenylpropanoic acid

Procedure

Reaction of ethyl 4-(2-ethoxycarbonylbenzyloxy)-α-methylphenylacetate with potassium hydroxide by the method described in Example 1c provides colorless crystals, m.p. 145°-146° C. of 4-(2-carboxybenzyloxy)-α-methylphenylacetic acid.

Sources & evidence

ORD record: ord-eaffdf2f84724a52a269d9654f944eb2
Source dataset: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04816591

Reaction notes

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