Thionyl Chloride → HCID 14848847, compound

HRID 1195098Notes

Reaction equation

HRID 1195098 reaction equation
[CH2:1]([C:11]1[CH:12]=[N:13][C:14]([C:17]2[CH:25]=[CH:24][C:20]([C:21](O)=[O:22])=[CH:19][CH:18]=2)=[N:15][CH:16]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].S(Cl)([Cl:28])=O>>[CH2:1]([C:11]1[CH:12]=[N:13][C:14]([C:17]2[CH:25]=[CH:24][C:20]([C:21]([Cl:28])=[O:22])=[CH:19][CH:18]=2)=[N:15][CH:16]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 146458194-(5-Decylpyrimidin-2-yl)benzoic acid2×

Product 1

HCID 14848847HCID 14848847, compoundYield 99.6%

Procedure

4-(5-n-Decyl-2-pyrimidyl)benzoic acid (2.0 g) prepared in the above (3) was added to thionyl chloride (10 g) and a slight amount of N,N-dimethylformaide was added thereto and the mixture was refluxed for 4 hours. Excess thionyl chloride was distilled off to obtain the titled compound (2.1 g).

Workup

  1. additiona slight amount of N,N-dimethylformaide was added
  2. temperaturethe mixture was refluxed for 4 hours
  3. distillationExcess thionyl chloride was distilled off

Sources & evidence

ORD record
ord-7efde1339a594cc7b6e9bb0976ea960e
Source dataset
uspto-grants-1992_05
Patent number
US05110496

Reaction notes

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