HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1195127Generated: November 2, 2026
Dicyclohexylcarbodiimide → [Nalpha-t-Butoxycarbonyl-beta-(4-thiazolyl) alanyl]-glycine t-butyl ester
https://huagongshe.com/reaction/1195127
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Glycine tert-butyl ester | HCID 151417 | — |
| Reactant | (S)-2-((tert-Butoxycarbonyl)amino)-3-(thiazol-4-yl)propanoic acid | HCID 2734486 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | [Nalpha-t-Butoxycarbonyl-beta-(4-thiazolyl) alanyl]-glycine t-butyl ester | HCID 53829975 | 110.2% |
Reaction Steps
Dicyclohexyl carbodiimide (226 mg) was added to a solution of 273 mg of Nα -t-butoxycarbonyl-β-(4-thiazolyl)-L-alanine and 132 mg of glycine t-butylester in 5 ml of ethyl acetate at 0° C. The reaction solution was stirred at 0° C. for 0.5 hour, then at ambient temperature for 18 hours. 4 drops of glacial acetic acid was then added to the reaction mixture and the mixture filtered. The filtrate was concentrated under vacuum to provide 426 mg of the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05110799 |
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| Source dataset | uspto-grants-1992_05 |
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| ORD ID | ord-c6e52115daf34ea7a66c1eae8ffb8c85 |
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| Source note | uspto-grants-1992_05 |
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