反应详情

A stirred solution of 1.29 g of the ester from Example 20 (step A) in 3.5 ml of methylene chloride was treated with 3.5 ml of trifluoroacetic acid and the solution stirred 2.5 hours at ambient temperature. The solution was then concentrated under a stream of nitrogen and the residue dissolved in methylene chloride/diethyl ether. The solution was washed 2 times with saturated aqueous sodium carbonate solution and the organic phase was then dried with sodium sulfate and filtered. Concentration under vacuum provided 919 mg of the title compound as a yellow oil.

1. concentrationThe solution was then concentrated under a stream of nitrogen
2. dissolutionthe residue dissolved in methylene chloride/diethyl ether
3. washThe solution was washed 2 times with saturated aqueous sodium carbonate solution
4. dry with materialthe organic phase was then dried with sodium sulfate
5. filtrationfiltered
6. concentrationConcentration under vacuum