Thioglycolic Acid → HCID 54468475, compound

HRID 1195286Notes

Reaction equation

HRID 1195286 reaction equation
[CH:1]([C:5]1[CH:13]=[CH:12][C:8]2[O:9][CH2:10][O:11][C:7]=2[CH:6]=1)=[CH:2][CH2:3][CH3:4].[SH:14][CH2:15][C:16]([OH:18])=[O:17]>C(OCC)(=O)C>[O:9]1[C:8]2[CH:12]=[CH:13][C:5]([CH2:1][CH:2]([S:14][CH2:15][C:16]([OH:18])=[O:17])[CH2:3][CH3:4])=[CH:6][C:7]=2[O:11][CH2:10]1

Participants

4

Reactant 2

HCID 1133Thioglycolic AcidHCID 544428065-(But-1-en-1-yl)-2H-1,3-benzodioxole

Product 1

HCID 54468475HCID 54468475, compoundYield 53.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2.2 g of 5-(1-butenyl)-1,3-benzodioxole and 5.4 g of mercaptoacetic acid were heated at 60° C. for 3 h. The reaction mixture was diluted with ethyl acetate, washed with water and an aqueous common salt solution and dried over magnesium sulfate. The solvent was distilled off and the product was separated according to silica gel column chromatography (chloroform) to obtain 1.8 g of the intended compound in the form of a colorless oil.

Workup

  1. washwashed with water
  2. dry with materialan aqueous common salt solution and dried over magnesium sulfate
  3. distillationThe solvent was distilled off
  4. customthe product was separated

Sources & evidence

ORD record
ord-14484b7157b448bd88300314c6b7fcc5
Source dataset
uspto-grants-1992_05
Patent number
US05110956

Reaction notes

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