反应详情

14.52 g of 2-(1,3-benzodioxol-5-yl)-2-propanol was dissolved in 200 ml of benzene, followed by the addition of a catalytic amount of p-toluenesulfonic acid monohydrate. The obtained mixture was heated under reflux in a short-neck Kieldahl flask fitted with a Dean-Stark reflux condenser for 2.5 hours. The reaction mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate and a saturated aqueous solution of common salt successively, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated to obtain 14.33 g of the title compound as an oil.

1. temperatureThe obtained mixture was heated
2. temperatureunder reflux in a short-neck Kieldahl flask
3. customfitted with a Dean-Stark
4. temperaturereflux condenser for 2.5 hours
5. washThe reaction mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate
6. dry with materiala saturated aqueous solution of common salt successively, dried over anhydrous magnesium sulfate
7. filtrationfiltered
8. concentrationThe filtrate was concentrated