Dimethylamine → HCID 178483050, compound

Participants

Reaction Steps

Xanthine (2,6-dihydroxy-9H-purine) is converted by reaction with phosphorus oxytrichloride in accordance with G. B. Elion and G. H. Hitchings, J. Am. Chem. Soc. 78, 3508 (1956) into the 2,6-dichloro-9H-purine and the latter is reacted with N,N-dimethylamine in accordance with J. A. Montgomery and L. B. Holum, J. Am. Chem. Soc. 80, 404 (1958) to form 2-chloro-6-(N,N-dimethylamino)-9H-purine.

Provenance & Evidence